Monosynaptic excitatory post-synaptic potentials (EPSPs) produced in spinal motoneurones of the cat by stimulation of a single afferent fibre were recorded with. Synaptic potentials are excitatory or inhibitory, depending upon the nature of the transmitter released and the postsynaptic receptor. In the mammalian CNS, the. The result of chemical transmission of a nerve impulse at the synapse (neuronal junction), the postsynaptic potential can lead to the firing of a new impulse.


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Join professional personal and executive Coaches along with managers and leaders who have Coaching roles in this exciting upcoming Neuroscience for Coaches programme.

Perhaps you have heard about the release of this content packed book by the same name? Or maybe you have spoken to one of the graduates of the live programme? Ions flowing through the channels create a shift in the resting membrane polarization, which usually has a slightly more negative charge inside the neuron than outside.

Hyperpolarization —that is, an increase in negative charge on the inside of the neuron—constitutes an inhibitory PSP, because it inhibits the synaptic potential from firing an impulse.


Synaptic potentials are small and many are needed to add up to reach synaptic potential threshold. The two ways that synaptic potentials can add up to potentially form an action potential are spatial summation and temporal summation.

Spatial summation refers to several excitatory stimuli from different synapses converging on the same postsynaptic neuron at the same time to reach the threshold needed to reach an action potential. Temporal summation refers to successive excitatory stimuli on the same location of the postsynaptic neuron.

Postsynaptic potential

Both types of summation are the result of adding together many excitatory potentials. B Electrical responses to synaptic activation. In short, the summation of EPSPs and IPSPs by a postsynaptic neuron permits a neuron to integrate the electrical information provided by all the inhibitory and synaptic potential synapses acting on it at any moment.

Whether the sum of active synaptic inputs results in the production of an action potential depends on the balance between excitation and inhibition.

Summation of Synaptic Potentials - Neuroscience - NCBI Bookshelf

Excitatory synaptic action in motoneurones. Quantal components of the end-plate potential. The different time synaptic potential of minimal EPSPs in spinal motoneurones.